Generally a weight equal to the reciprocal of the variance is applied to the data.Įquation 22.3.1 Ideally the Weight for each data point will be equal or proportional to the Variance of the Data PointĪnother very useful feature of non-linear regression analysis is that we can fit more than one line simultaneously. Thus data that are very accurately known can be analysed with data that are less accurately know by assigning a higher weight to the better data. Using non-linear regression analysis it is possible to assign a specific variance (or weight) to each data point that is appropriate the measurement. This is not generally the case as for example with ARE plots for urine data analysis. It is fortunate that taking the log of the y-value (usually concentration) results in a reasonable representation of the variance. A problem with transforming the data is that the variance or error in each data point can be distorted inappropriately. It may be possible to transform the data, for example by taking the log of the y value, but a straight line is still necessary. A major limiting feature is that it must be possible to represent the data with a straight line. Other useful pharmacokinetic programs are listed on this page.Īlthough graphical methods, such as we have used throughout this course, can be quite useful there are some significant limitations. Other programs used for non-linear regression analysis of pharmacokinetic data include SAAM II (Reference ), WinNonlin (Reference ) and ADAPT (Reference ).
#Winnonlin user guide how to
In this section I will briefly describe how to set up one non-linear regression program, Boomer, which can be used in the analysis of pharmacokinetic data. Previous | next Analysis using a Non-linear Regression Program
#Winnonlin user guide manuals
In the case of computer applications, it is usual to include screenshots of the human-machine interface(s), and hardware manuals often include clear, simplified diagrams.Chapter 22 - Chapter 22 Non-Linear Regression Analysis of Individual Subject Data
Most user guides contain both a written guide and the associated images. User guides are most commonly associated with electronic goods, computer hardware and software. Better yet, this template explains why the important things are important and how you go about getting them. Think of it as a framework for you to build what's important in your life.
#Winnonlin user guide manual
The Personal User Guide is an organized instruction manual dedicated to you. It is usually written by a technical writer, although user guides are written by programmers, product or project managers, or other technical staff, particularly in smaller companies.
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